© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

People regularly encounter metaphors in a variety of different communicative settings, but most studies of metaphor framing have relied exclusively on written materials. Across three experiments (N...

Bermúdez persuasively argues that framing effects are not as irrational as commonly supposed. In focusing on the reasoning of individual decision-makers in complex situations, however, he neglects the crucial role of the social-communicative context for eliciting certain framing effects. We contend that many framing effects are best explained in terms of basic, rational principles of discourse processing and pragmatic reasoning.

International Humanitarian Law mandates that all wounded in war, no matter which party they belong to, shall receive aid in accordance with their medical condition, and that “there shall be no distinction among them founded on any grounds other than medical ones.” This principle of impartiality is endorsed by various other military and civilian institutions worldwide to include the ICRC, the US Department of Defense, and the American Medical Association. In this essay, I argue that in some cases, we ought, (...) morally speaking, to triage based on factors beyond one’s medical condition. More specifically, I argue that in these cases, we ought to triage, at least partly, based on one’s moral responsibility for one’s current medical predicament. I call this view Triage by Moral Responsibility (TMR). I support my argument for TMR by demonstrating its plausibility when applied to cases of medical treatment and disaster relief, and by drawing parallels between these situations and those considered in the ethics of defensive harming. I conclude by discussing the practicality of my moral conclusion for the practice of medical triage in pandemics and war. (shrink)

This essay constitutes a brief survey of what Christians believe about forgiveness. After describing what is stake and noting the connection between forgiveness and amendment of life, it considers two questions in particular. Firstly, is forgiveness conditional on repentance? Secondly, is forgiveness compatible with resentment? It concludes by giving priority to the question of truth when we consider the appropriateness of forgiveness.

In a pair of articles published in Faith and Philosophy, C. Stephen Evans argues that Kierkegaard’s pseudonym, Johannes Climacus, understands religious experience as the transforming power of an encounter with the love of God. However, in a book published under his own name, Kierkegaard gives a quite different picture of Christian experience. For Self-Examination makes clear that the reception of God’s love is a rebirth that can occur in the believer only insofar as he or she has died to (...) the world - to all possessions, even to the possession of God’s love. According to Kierkegaard, this “dying to” is the truly transforming experience that characterizes Christian spirituality, and that provides the condition for a life infused with faith, hope, and love. (shrink)

In a pair of articles published in Faith and Philosophy, C. Stephen Evans argues that Kierkegaard’s pseudonym, Johannes Climacus, understands religious experience as the transforming power of an encounter with the love of God. However, in a book published under his own name, Kierkegaard gives a quite different picture of Christian experience. For Self-Examination makes clear that the reception of God’s love is a rebirth that can occur in the believer only insofar as he or she has died to (...) the world - to all possessions, even to the possession of God’s love. According to Kierkegaard, this “dying to” is the truly transforming experience that characterizes Christian spirituality, and that provides the condition for a life infused with faith, hope, and love. (shrink)

It is an irony that Kierkegaard would have relished that Marilyn Piety’s review in The Owl, 21, 2 : 205–208, of my book, Kierkegaard’s Dialectic of Inwardness, was published in a journal dedicated to Hegel studies and read by Hegel scholars. For her criticisms are typical of those for whom Kierkegaard is the David who slew forever the Goliath of Hegelianism. Thus it is not really, as she states, a lack of “substance” that disturbs her about my book; it is (...) the entire project, the very effort to show how much Kierkegaard continued to write books susceptible to Hegelian dialectical analysis long after he had turned his rhetorical weapons in Hegel’s direction. I am grateful to the editors of The Owl for this opportunity to try to convey to Hegel scholars a bit of my own excitement over what I believe is indeed a substantial discovery within the vexed field of Kierkegaard scholarship. (shrink)

Interpretation pervades human thinking. Whether perception or experience, spoken word or written theory, whatever enters our consciousness must be interpreted in order to be understood. Every area of inquiry—art and literature, philosophy and religion, history and the social sciences, even many aspects of the natural sciences—involves countless opportunities to interpret the object of inquiry according to very different paradigms. These paradigms may derive from the language we speak, the nature of our education, or personal preferences. The abundance and diversity of (...) paradigms make interpretation both fascinating in its complexity and often frustrating for the conflicts it generates. In _Dialectical Readings_, Dunning distinguishes three types of interpretation, each defined in terms of a distinctive dialectical way of thinking: theoretical interpretation, which assumes binary oppositions; transactional interpretation, which seeks reciprocal relations; and transformational interpretation, which discerns paradoxical meanings. Dunning offers new and insightful readings of familiar texts by B. F. Skinner, Claude Lévi-Strauss, Lee Benson, Roland Barthes, Friedrich Nietzsche, and Michel Foucault and sheds new light on works by Thomas Kuhn, Joseph Campbell, Reinhold Niebuhr, Søren Kierkegaard, Paul Tillich, and Paul Ricoeur. _Dialectical Readings _enables readers to recognize diverse dialectical approaches to understanding—their own as well as those of others—in a way that provides new and helpful insights into a wide variety of subjects in which conflicting interpretations abound. (shrink)

Interpretation pervades human thinking. Whether perception or experience, spoken word or written theory, whatever enters our consciousness must be interpreted in order to be understood. Every area of inquiry—art and literature, philosophy and religion, history and the social sciences, even many aspects of the natural sciences—involves countless opportunities to interpret the object of inquiry according to very different paradigms. These paradigms may derive from the language we speak, the nature of our education, or personal preferences. The abundance and diversity of (...) paradigms make interpretation both fascinating in its complexity and often frustrating for the conflicts it generates. In _Dialectical Readings_, Dunning distinguishes three types of interpretation, each defined in terms of a distinctive dialectical way of thinking: theoretical interpretation, which assumes binary oppositions; transactional interpretation, which seeks reciprocal relations; and transformational interpretation, which discerns paradoxical meanings. Dunning offers new and insightful readings of familiar texts by B. F. Skinner, Claude Lévi-Strauss, Lee Benson, Roland Barthes, Friedrich Nietzsche, and Michel Foucault and sheds new light on works by Thomas Kuhn, Joseph Campbell, Reinhold Niebuhr, Søren Kierkegaard, Paul Tillich, and Paul Ricoeur. _Dialectical Readings _enables readers to recognize diverse dialectical approaches to understanding—their own as well as those of others—in a way that provides new and helpful insights into a wide variety of subjects in which conflicting interpretations abound. (shrink)

An “objectified God” does not satisfy. On this point, surely all will agree with Doctor Marti. To seek an “objectivie essence” behind God’s presence is implicitly to deny the reality of that presence. In subjecting the idea of God to ratiocination, the absoluteness and infinity of God are compromised, for a God-object must assume a particular existence over against the divine essence, and thereby abandon God’s freedom to be, the divine essence as pure relation. On this, reason and faith are (...) in perfect harmony: when God is reduced to an object, it is no longer God that is in view. (shrink)

The SSIS SEL Brief Scales are multi-informant measures that were developed to efficiently assess the SEL competencies of school-age youth in the United States. Recently, the SSIS SELb was translated into multiple languages for use in a multi-site study across six European countries. The purpose of the current study was to examine concurrent and predictive evidence for the SEL Composite scores from the translated versions of the SSIS SELb Scales. Results indicated that SSIS SELb Composite scores demonstrated expected positive concurrent (...) and predictive relationships with scores from the Connor-Davidson Resilience Scale and negative relationships with scores from the problem behavior scales of the Strengths and Difficulties Questionnaire. Although there were a few exceptions, these patterns generally were consistent across informants and samples providing initial validity evidence for the Composite score from the translated versions of the SSIS SELb Scales. Limitations and future research directions are discussed. (shrink)

Parts of the body are often embedded in the structure of compound words, such as heartbreak and brainchild. We explored the relationships between the semantics of compounds and their constituent body parts, asking whether these relationships are largely arbitrary or instead reflect deeper metaphorical mappings shared across languages and cultures. In three studies, we found that U.S. English speakers associated the English translation equivalents of Chinese compounds with their constituent body parts at rates well above chance, even for compounds with (...) highly abstract meanings and even when accounting for the semantic relatedness of the compounds and body parts. English speakers in India and Chinese speakers in Hong Kong showed similar intuitions about these associations. Our results suggest that the structure of compound words can provide insight into cross‐culturally shared ways of connecting meaning to the body. (shrink)

The central theme of this book is that the intentional aspects of mental processes are explicable, with mathematics, as due to the operation of purely material brain mechanisms. Nelson's version of mechanism holds that "a being has a mind if and only if its body or certain bodily parts are guided by formally distinct rules of a complexity to account for intentionality, and it is capable of conscious feeling". But he limits his inquiry to an investigation of the first of (...) these two conditions only: "So far as I can see, mechanism as such has nothing whatever to say about the relationship between physical states and states of awareness such as pains and ideas, although it does specifically address itself to the understanding of cognition, intelligence, and other such attributes of mind". (shrink)

The task of comparing and contrasting philosophical opponents is perhaps more difficult methodologically than any other enterprise in the historiography of thought. If the historian attempts to suppress his or her own opinions, the resulting illusion of impartiality will immediately arouse the suspicions of critical readers. If, on the other hand, the writer openly confesses a preference for one of the subjects, then all those who gravitate toward the other will certainly be offended - and it is usually to them (...) that editors will send the book for “review”! This is not simply a matter of straightforward confessions of agreement: the interpreter’s orientation will affect every decision of organization and style, of method in the fullest sense of the word. As Stephen Crites pointedly commented at the end of his own fine work on Hegel and Kierkegaard. (shrink)

The task of comparing and contrasting philosophical opponents is perhaps more difficult methodologically than any other enterprise in the historiography of thought. If the historian attempts to suppress his or her own opinions, the resulting illusion of impartiality will immediately arouse the suspicions of critical readers. If, on the other hand, the writer openly confesses a preference for one of the subjects, then all those who gravitate toward the other will certainly be offended - and it is usually to them (...) that editors will send the book for “review”! This is not simply a matter of straightforward confessions of agreement: the interpreter’s orientation will affect every decision of organization and style, of method in the fullest sense of the word. As Stephen Crites pointedly commented at the end of his own fine work on Hegel and Kierkegaard. (shrink)

To those who would classify Hegel either as an atheist or as a pantheist, Joachim Ringleben’s study of his theory of sin provides a clear and comprehensive challenge. The theme of sin in Hegel’s thought is prima facie an important one, notwithstanding the fact that no other book on Hegel’s philosophy of religion has treated it in depth. This lacuna may account for Ringleben’s omission of the customary review of scholarship. Aside from a few footnotes, his study deals exclusively with (...) Hegel’s writings, interrupting its exposition only several times to discuss criticisms put forward by Kierekgaard and Müller in the 19th century. Accordingly, this review will first indicate the general thrust of the expository chapters, noting highlights rather than attempting summaries, and then turn to the question of critical evaluation of Hegel’s theory. (shrink)

To those who would classify Hegel either as an atheist or as a pantheist, Joachim Ringleben’s study of his theory of sin provides a clear and comprehensive challenge. The theme of sin in Hegel’s thought is prima facie an important one, notwithstanding the fact that no other book on Hegel’s philosophy of religion has treated it in depth. This lacuna may account for Ringleben’s omission of the customary review of scholarship. Aside from a few footnotes, his study deals exclusively with (...) Hegel’s writings, interrupting its exposition only several times to discuss criticisms put forward by Kierekgaard and Müller in the 19th century. Accordingly, this review will first indicate the general thrust of the expository chapters, noting highlights rather than attempting summaries, and then turn to the question of critical evaluation of Hegel’s theory. (shrink)

War metaphors are ubiquitous in discussions of everything from political campaigns to battles with cancer to wars against crime, drugs, poverty, and even salad. Why are warfare metaphors so common, and what are the potential benefits and costs to using them to frame important social and political issues? We address these questions in a detailed case study by reviewing the empirical literature on the subject and by advancing our own theoretical account of the structure and function of war metaphors in (...) public discourse. We argue that war metaphors are omnipresent because they draw on basic and widely shared schematic knowledge that efficiently structures our ability to reason and communicate about many different types of situations, and they reliably express an urgent, negatively valenced emotional tone that captures attention and motivates action. Nevertheless, we find that the meaning of war metaphors is intimately tied to the context in which they are used, which may result in either positive or negative outcomes, depending on the situation. Thus, blanket statements about whether or not a war frame is useful are misguided or overly constraining. Here we situate our case study results in relation to popular theories of metaphoric representation and processing and offer some guidelines for using a war framing effectively. This work helps illuminate the complex, dynamic, and nuanced functions of metaphor in cognition in general, and in public discourse in particular. (shrink)

The Flourishing Enterprise Strategy Design Method is a robust procedure that helps leaders craft effective enterprise strategies in our increasingly volatile, uncertain, complex and ambiguous world. Informed by the latest science and practice, it enables leaders to create strategic paths for enterprises and their stakeholders to improve their performance financially, socially and environmentally. The method integrates business design and strategy techniques with vital science-based principles for flourishing. From an overall process perspective, the method employs the backcasting approach. From a strategic (...) planning standpoint, the method hosts a strategic conversation about the stakeholder’s definition of success for the enterprise considering science-based principles. This occurs during an iterative co-creative systemic-design process focused on business modelling. Business modelling is enabled by the Flourishing Business Canvas: an innovative visual design tool aligned with the science-based principles. A case study of a medium-sized manufacturing business illustrates how the method is applied. Finally, the case is made for swift adoption of these innovative strategy methods by enterprises in all sectors and sizes to enable their powerful response to current climate challenges, to the UN Sustainable Development Goals, and to go beyond to ensure the conditions for all life to flourish are re-enabled for future generations. (shrink)

Political discourse is saturated with metaphor, but evidence for the persuasive power of this language has been hard to come by. We addressed this issue by investigating whether voting intentions were affected by implicit mappings suggested by a metaphorically framed message, drawing on a real-world example of political rhetoric about the federal budget. In the first experiment, the federal budget was framed as similar to or different from a household budget, though the information participants received was identical in both conditions. (...) When the federal budget was described as similar to a household's, people considered the personal finances of a presidential candidate more relevant—a finding we replicated in a larger, pre-registered study. In a follow-up experiment, we presented participants with a more explicit rhetorical argument and found a similar effect, moderated by political affiliation. These studies illuminate how metaphorical comparison affects cognition for important real-world issues, sometimes in unintended ways. (shrink)

A critical survey of various positions on the nature, use, possession, and analysis of normative concepts. We frame our treatment around G.E. Moore’s Open Question Argument, and the ways metaethicists have responded by departing from a Classical Theory of concepts. In addition to the Classical Theory, we discuss synthetic naturalism, noncognitivism (expressivist and inferentialist), prototype theory, network theory, and empirical linguistic approaches. Although written for a general philosophical audience, we attempt to provide a new perspective and highlight some underappreciated problems (...) about normative concepts. (shrink)

Most donated organs in the United States come from brain dead donors, while a small percentage come from patients who die in “controlled,” or expected, circumstances, typically after the family or surrogate makes a decision to withdraw life support. The number of organs available for transplant could be substantially if donations were permitted in “uncontrolled” circumstances–that is, from people who die unexpectedly, often outside the hospital. According to projections from the Institute of Medicine, establishing programs permitting “uncontrolled donation after circulatory (...) determination of death,” or uDCDD, throughout the United States has the potential to provide 22,000 more donation opportunities annually. In contrast, U.S. controlled donation after circulatory determination of death, or cDCDD, cases have increased progressively over the past decade from 87 to 848 donors, but currently account for only 10.6 percent of all deceased donors. Following the IOM recommendations, several projects exploring the feasibility of uDCDD were funded by the federal government, including a grant from the Health Resources and Services Administration that supported a pilot project in New York City in which the authors of this article participated.A key feature of our protocol, and indeed of many uDCDD protocols, is the initiation of preservation methods such as chest compressions and extracorporeal membrane oxygenation shortly after death in order to perfuse and preserve the donor's organs. Critics of uDCDD argue that the means of determining death deviates from generally ascribed principles. They assert that reinstituting circulation in order to preserve organs has the effect of “undoing” the prior determination of death. The result is that cDCDD is widely accepted and practiced routinely even though it only marginally increases the number of organs available for transplantation, and uDCDD is widely considered unacceptable despite being ethically embraced and proven to significantly increase organ donation opportunities in other countries. This article explores the evolution of this counterintuitive state of affairs and calls for a policy that, in line with the IOM report, allows for both cDCDD and uDCDD protocols. (shrink)

We address a previous finding in the business ethics literature in which accounting professionals in higher rank levels, i.e., “manager” or “partner” of auditing firms, appear to have lower moral reasoning ability than their junior counterparts. Prior investigations have relied upon a similar methodology for estimating ethical beliefs, namely testing “moral reasoning ability” using either the Moral Judgment Interview or Defining Issues Test. In the present study, we use a multiple vignettes approach to test for the existence of the inverse (...) rank-ethical beliefs effect. With only 2 of the 30 vignettes resulting in both managers and partners being more accepting of the ethically charged behaviors, the results presented here using this alternative methodology are generally not supportive of the inverse rank-ethical beliefs phenomenon. We also use a multivariate analysis in order to control for demographic characteristics. Our results suggest that the most robust predictor of ethical attitudes among accounting practitioners is age, not rank within a firm. (shrink)